Regenerative Skin Technologies - The Difference between Exosomes and Rejuran

At Le Skin Code, we offer two new standout regenerative technologies—Exosomes and Rejuran—powerful, non-surgical options for clients seeking visible skin rejuvenation and long-term skin health. To break it down I have put together a quick read comparing how both technologies work.

Exosomes (XO Derm Pro)

Applied topically after Skin Needling and PDO Threads.

Exosomes are nano-sized extracellular vesicles naturally secreted by stem cells. They are rich in growth factors, peptides, and genetic material, and they act as messenger type cells, enhancing cell-to-cell communication and stimulating the skin’s natural repair processes.

Key Benefits:

  • Stimulates collagen and elastin synthesis

  • Reduces inflammation and accelerates wound healing

  • Enhances skin barrier repair and hydration

  • Improves tone, texture, and pore refinement over time

We use XO Derm Pro, an advanced exosome technology derived human umbilical wharton’s jelly mesenchymal stem cells which have been proven to deliver increased bioactivity in post-procedure healing and skin rejuvenation.

Rejuran Polynucleotides (PN)

Injected superficially (intradermal) to full face, neck, decolletage, hands. Most common area to treat is around the eyes.

Rejuran is formulated with polynucleotides (PN), highly purified DNA fragments derived from wild salmon. These nucleotides activate the skin's own healing mechanisms, improving cellular turnover and supporting dermal remodeling.

Key Benefits:

  • Boosts fibroblast activity and promotes collagen synthesis

  • Improves skin elasticity and wrinkle depth

  • Restores skin integrity and reduces micro-inflammation

  • Ideal for treating ageing, redness, scars, and textural irregularities

Together, Exosomes and Rejuran offer a synergistic approach to skin regeneration, ideal for clients looking to repair, strengthen, and future-proof their skin with clinically-backed science.

 

danielle walker